Characteristics and Patterns of Metastatic Disease from Chordoma
نویسندگان
چکیده
Chordoma is a rare, slow-growing malignant tumor arising from notochordal remnants. A retrospective review of patient records at two major referral centers was undertaken to assess the incidence, location, and prognostic factors of metastatic disease from chordoma. 219 patients with chordoma (1962-2009) were identified. 39 patients (17.8%) developed metastatic disease, most frequently to lung (>50%). Median survival from the time of initial diagnosis was 130.4 months for patients who developed metastatic disease and 159.3 months for those who did not (P = 0.05). Metastatic disease was most common in the youngest patients (P = 0.07), and it was 2.5 times more frequent among patients with local recurrence (26.3%) than in those without (10.8%) (P = 0.003). Patient survival with metastatic disease was highly variable, and it was dependent on both the location of the tumor primary and the site of metastasis. Metastasis to distal bone was the most rapid to develop and had the worst prognosis.
منابع مشابه
Cutaneous Metastasis from Sacral Chordoma: A Case Report
Chordoma is a malignant, slow growing and locally aggressive tumor. It arises from remnants of the notochord and accounts for 1–4% of all primary bone tumors. They usually arise from anywhere along the spine, from base of the skull to the sacrococcygeal area and usually do not metastasize. Chordomas are slow-growing tumors which are not responsive to conventional chemotherapy or radiation. They...
متن کاملMetastatic disease from spinal chordoma: a 10-year experience.
OBJECT Metastastic lesions have been reported in 5 to 40% of patients with spinal and sacrococcygeal chordoma, but few contemporary series of chordoma metastastic disease exist in the literature. Additionally, the outcome in patients with chordoma-induced metastastic neoplasms remains unclear. The authors performed a retrospective review of the neurosurgery database at the University of Texas M...
متن کاملA vertebral extra dural chordoma at C5, possibly deriving from a clival chordoma
BACKGROUND Clival chordomas are a rare type of cancer with low metastatic potential and primary metastasize to the lung or bones. CASE DESCRIPTION This case report describes a possible metastatic, paravertebral chordoma at level C4-C5 in a patient with a past medical history of a clival chordoma. CONCLUSION Chordomas are unpredictable and may metastasise.
متن کاملPulmonary metastatic chordoma treated with platinum-based chemotherapy; A case report
Chordoma is a rare malignant neoplasm arising from remnants of notochordal cells along the spinal axis. It occurs along the spinal axis with most tumors arising in the sacrococcygeal and sphenooccipital regions, with the remaining tumors arising along the cervical, thoracic, and lumbar spine. As the chordoma has been considered primarily a local disease associated with a high incidence of local...
متن کاملMetastatic Chordoma: Report of the Two Cases and Review of the Literature.
Chordomas are rare malignant bone tumours with a predilection for the axial skeleton, especially the sacrum and skull base. Median survival in patients with metastatic disease is usually dismal. Treatment is challenging due to the propensity for local recurrence, metastatic disease as well as lack of clear consensus regarding the optimal management. Our case report highlights two cases of sacra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2015 شماره
صفحات -
تاریخ انتشار 2015